We've known for years that pregnant women that consume Anti-TNF antibodies such as etanercept and many other such drugs, that the transfer of these monoclonal IgG molecules into the fetus is highest during the last trimester of pregnancy. This new study suggests that most moms can stop the use of these drugs in the 30th week of gestation and reduce the exposure of the infant to these drugs and also reduce the moms relapse into Crohn's and Ulcerative colitis. This of course depends on the mom's medical condition.
This article clearly suggests that it may be beneficial to continue breastfeeding and infant in a mother who has been consuming opiates, particularly those dependent on opiates. They suggest it may actually reduce infant withdrawal somewhat.
A new and novel treatment for POSTPARTUM DEPRESSION has just been introduced and is indicated for severe refractory PPD. Derived from the natural steroid hormone, allopregnanolone, this novel steroid acts directly in the brain to reduce depression. Its only problem is that it requies a 60 hour IV infusion of drug in a clinical environment. Studies show it is highly effective. Again, its indicated for SEVERE refractory PPD.
This study suggests that Daily use of HIGH potency cannabis may be associated with higher rates of pyschosis. Daily users of high potency cannabis were 5 times more likely to encounter Psychosis.
(My take on this...) Cannabis has a high attraction for lipid rich adipose (fatty) tissue. Once filled with daily use of high levels of THC, plasma levels probably rise signficantly leading to super high levels of THC in the brain leading to Psychosis.
Large study of 1 791 520 Swedish children suggests fetal exposure to a maternal infection while hospitalized increased the risk for autism and depressionthat.
A new IV drug was just released for the treatment of Postpartum Depression. Called Brexanolon (Zulresso), it requires a continuous infusion over 60 hours.
Excellent article that covers the use of anticonvulsants during pregnancy. As expected Valproic acid is the worst and should be avoided. Folic Acid is greatly beneficial to the fetus. Not much data on the newer anticonvulsants but many are safer. Good read.
While malaria during pregnancy dramatically increases fetal complications, apparently the drugs might do so as well. 18.5% of exposed pregnancies resulted in miscarriage and 11.8% were elective terminations.