Risk of Ocular Anomalies in Children Exposed in Utero to Antimalarials: A Systematic Literature Review.

This extensive review answered one of my long-time questions: Do the antimalarials cause ophthalmic damage when used in infancy?  This extensive reveiw suggests they don't and are apparently reasonably safe to use,  even in Breastfeeding mothers which we are asked about all the time.

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Update - Lithium in the Long-Term Treatment of Bipolar Disorders

This article is interesting in that it suggests that Lithium therapy may be linked to reduced risk of Alzheimer's diseas and stroke.

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Determination of Mesalamine levels in Human Milk as a Function of Dose.

This recently published study from my laboratories shows that levels of Mesalamine (5-Aminosalicylic acid) in human milk are exceedingly low. Despite the dose,  the relative infant doses in these 10 moms  (RID) were all lower than 0.1%.  Good news,  moms can safely use these products for ulcerative colitis and Crohn's disease.

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Apparent Pediatric allergy to secondhand marijuana smoke.

Pediatric allergy to secondhand marijuana smoke

A six year old boy with severe asthma, which was not responding to treatment, was found to be allergic to secondhand marijuana smoke. He had daily symptoms of cough, shortness of breath and wheezing. It was discovered that some family members had started smoking marijuana in the house, although never in the same room as the boy.

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Safety of Contrast Material Use During Pregnancy and Lactation

This is an excellent article that reviews the current knowledge about the use of various iodinated and gadoliniium-containing radio contrast agents used in CT and MRI scans. While the iodinated compounds are probably safe to use in breastfeeding mothers,  there is some concern over the "repeated" use of the metal-containing gadoliniium products used for MRI scans.  Excellent review of this subject.  TWH

SUMMARY from this article:

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Longer lactation duration is associated with decreased prevalence of non-alcoholic fatty liver disease in women.

A longer duration of breastfeeding has been associated with multiple potential health benefits for the mother including reduction in heart disease, diabetes and certain cancers. In this study we found that breastfeeding for longer than 6 months was associated with a lower risk of non-alcoholic fatty liver disease in mid-life.

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Pediatric allergy to secondhand marijuana smoke

This article clearly suggests your should not breastfeed in close proximity to your children.

 

Pediatric allergy to secondhand marijuana smoke

Seattle, Washington

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Association between exposure to macrolides and the development of infantile hypertrophic pyloric stenosis: a systematic review and meta-analysis

We've known for years that Erythromycin and perhaps azithromycin can cause pyloric stenosis in infants,  but we were cautious about its use during breastfeeding, or during pregnancy in mothers.  Seems from this data that erythromycin used during pregnancy or breastfeeding may not be associated with pyloric stenosis.  This is probably dose-related, and perhaps time dependent,  since levels in milk are low. This is good news.  Thus women can potentially use macrolide antibiotics while breastfeeding.  I still think they are not the best choice early postpartum in breastfeeding mothers and physicians should choose an alternate, just in case the first few months postpartum. 

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Breastfeeding Greater Than 6 Months Is Associated with Smaller Maternal Waist Circumference Up To One Decade After Delivery.

Breastfeeding studies continue to suggest that breastfed infants are lighter in body weight.  This is probably due to changes in gut microbiome, although this is not clear yet.  Good news,  breastfeed your baby and give them a lighter body weight in the future. 

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Anti-TNF Exposure during Pregnancy in Crohn's Disease Patients.

The use of 'biological' drugs that are derived from the IgG antibody, are gaining in popularity.  They are used in many syndromes today and are providing major changes in lifestyle for humans.  These drugs commonly work for all kinds of rheumatic or autoimmune syndromes and provide major lifestyle changes in patients.  Fortunately,  these IgG-type products don't transfer into breastmilk very well and therefore breastfeeding mothers can commonly use these products quite safely. 

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